OAS1 Gene Summary [Human]
This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]
Details
| Type | Protein Coding |
| Official Symbol | OAS1 |
| Official Name | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] |
| Ensembl ID | ENSG00000089127 |
| Bio databases IDs | |
| Aliases | 2'-5'-oligoadenylate synthetase 1, 2'-5' oligoadenylate synthase 1 |
| Synonyms | 2-5A SYNTHETASE, 2'5' OLIGOADENYLATE SYNTHETASE1, 2'-5' OLIGO A SYNTHETASE E, E18/E16, IFI-4, IMD100, OAS1A, OAS p40/46, OIAS, OIASI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- double-stranded RNA binding
- ATP binding
- enzyme
- protein binding
- 2'-5'-oligoadenylate synthetase
Pathways
Biological processes and signaling networks where the OAS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- systemic lupus erythematosus
- pulmonary alveolar proteinosis with hypogammaglobulinemia
- organismal death
- COVID-19
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- colon cancer
role in cell
- replication in
- activation in
- apoptosis
- expression in
- proliferation
- migration
- hydrogen peroxide resistance
- cell death
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- toll-like receptor 4 signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- response to virus
- glucose metabolic process
- defense response to bacterium
- surfactant homeostasis
- regulation of ribonuclease activity
- positive regulation of interferon-beta production
- glucose homeostasis
- toll-like receptor 3 signaling pathway
- defense response to virus
- negative regulation of chemokine (C-X-C motif) ligand 2 production
- positive regulation of tumor necrosis factor production
- negative regulation of IP-10 production
- negative regulation of viral genome replication
- interleukin-27-mediated signaling pathway
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- mitochondrion
- cytosol
- endoplasmic reticulum
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 2'-5'-oligoadenylate synthetase activity
- ATP binding
- protein binding
- double-stranded RNA binding
- metal ion binding