EIF2AK2 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Details
| Type | Protein Coding |
| Official Symbol | EIF2AK2 |
| Official Name | eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437] |
| Ensembl ID | ENSG00000055332 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2 alpha kinase 2, protein phosphatase 1, regulatory subunit 83, Protein Kinase RNA-activated, protein kinase RNA-regulated, Protein Kinase R |
| Synonyms | 2310047A08Rik, 4732414G15Rik, DAI, DKFZP586G0421, DOUBLE STRANDED RNA DEPENDENT protein KINASE, DYT33, EIF2AK1, eukaryotic translation initiation factor 2-alpha kinase 2, eukaryotic translation initiation factor 2-α kinase 2, IFNPKR, LEUDEN, p68 kinase, PKR, PPP1R83, PRKR, Tik |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF2AK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- double-stranded RNA binding motif (DSRM) superfamily
- protein phosphatase regulator
- coiled-coil domain
- leucine zipper domain
- PP1 binding domain
- Protein kinase domain
- identical protein binding
- alcohol group acceptor phosphotransferase
- double-stranded RNA binding
- basic domain
- Tyrosine kinase, catalytic domain
- ribonucleoprotein binding domain
- Protein kinase (unclassified specificity)
- dimerization domain
- eukaryotic translation initiation factor 2alpha kinase
- tetramerization domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- PKR interacting domain
- protein binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Double-stranded RNA binding motif
- pact binding motif
- hinge domain
- dsRNA-binding domain
- RNA-binding domain
Pathways
Biological processes and signaling networks where the EIF2AK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- EIF2 Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- PDGF Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- Huntington disease
- neoplasia
- leukemia
- epithelial cancer
- myelodysplastic syndrome
- acute myeloid leukemia
- tumorigenesis
- insulin resistance
- infection by human herpesvirus 1
role in cell
- binding in
- expression in
- proliferation
- apoptosis
- activation in
- phosphorylation in
- survival
- cell death
- degradation in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF2AK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- cellular response to amino acid starvation
- protein autophosphorylation
- regulation of NLRP3 inflammasome complex assembly
- positive regulation of MAPK cascade
- response to virus
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- translation
- endoplasmic reticulum unfolded protein response
- negative regulation of apoptotic process
- defense response to virus
- response to interferon-alpha
- positive regulation of chemokine production
- positive regulation of cytokine production
- negative regulation of translation
- negative regulation of viral genome replication
- negative regulation of osteoblast proliferation
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- RNA binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- double-stranded RNA binding
- protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- protein serine/threonine kinase activity
- kinase activity
- protein phosphatase regulator activity