CCL4 Gene Summary [Human]
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | CCL4 |
| Official Name | C-C motif chemokine ligand 4 [Source:HGNC Symbol;Acc:HGNC:10630] |
| Ensembl ID | ENSG00000275302 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 4 |
| Synonyms | ACT2, AT744.1, C-C motif chemokine ligand 4, G-26, HC21, LAG-1, macrophage inflammatory protein 1-β, MIP-1B, MIP1B1, MIP-1-beta, MIP-1-β, SCYA2, SCYA4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-10 helix
- dimerization domain
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- N-loop domain
- protein binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the CCL4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- CCR5 Signaling in Macrophages
- Chemokine Signaling
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Granulocyte Adhesion and Diapedesis
- Pathogenesis of Multiple Sclerosis
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- COVID-19
- diabetes mellitus
- septic shock
- heart failure
- systemic sclerosis
- idiopathic granulomatous mastitis
- glioma
- glioma formation
- chronic lymphocytic leukemia
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- activation in
- degradation in
- morphology
- migration
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- signal transduction
- positive regulation of calcium ion transport
- establishment or maintenance of cell polarity
- cell-cell signaling
- cell adhesion
- response to virus
- response to toxin
- positive regulation of GTPase activity
- positive regulation of calcium-mediated signaling
- inflammatory response
- immune response
- positive regulation of natural killer cell chemotaxis
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR1 chemokine receptor binding
- identical protein binding
- protein binding
- CCR chemokine receptor binding
- chemokine activity
- cytokine activity
- CCR5 chemokine receptor binding