MARCHF2 Gene Summary [Human]
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | MARCHF2 |
| Official Name | membrane associated ring-CH-type finger 2 [Source:HGNC Symbol;Acc:HGNC:28038] |
| Ensembl ID | ENSG00000099785 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 2 |
| Synonyms | 2-MAR, 9530046H09RIK, HSPC240, LOC51257, MARCH2, MARCH-II, membrane associated ring-CH-type finger 2, RGD1306395, Rgd1306395-predicted, RNF172 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCHF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- tail domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- septic shock
- preeclampsia
- infection by Listeria monocytogenes
role in cell
- replication in
- expression in
- cellular infiltration by
- ubiquitination in
- degradation in
- catabolism by
- K48 polyubiquitination in
- viral entry in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- high-density microsomal fractions
- cellular membrane
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCHF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endocytosis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- cytoplasmic vesicle
- cytosol
- endoplasmic reticulum
- endosome membrane
- Golgi membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding