TUBGCP5 Gene Summary [Human]
Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TUBGCP5 |
| Official Name | tubulin gamma complex associated protein 5 [Source:HGNC Symbol;Acc:HGNC:18600] |
| Ensembl ID | ENSG00000275835 |
| Bio databases IDs | |
| Aliases | tubulin gamma complex associated protein 5, gamma-tubulin complex component GCP5 |
| Synonyms | B130010C12Rik, GCP5, mKIAA1899, tubulin gamma complex component 5, tubulin, gamma complex component 5, tubulin γ complex component 5, tubulin, γ complex component 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBGCP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
- GCP5_NTD
- Gamma tubulin complex component N-terminal
- Gamma tubulin complex component C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- global developmental delay with intellectual disability
- obsessive-compulsive disorder
role in cell
- assembly
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUBGCP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle assembly
- meiotic cell cycle
- microtubule nucleation
- cytoplasmic microtubule organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- centrosome
- equatorial microtubule organizing center
- spindle pole
- cytosol
- gamma-tubulin large complex
- gamma-tubulin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule minus-end binding
- gamma-tubulin binding
- microtubule binding