Cav2 Gene Summary [Mouse]

This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

Details

Type
Protein Coding
Official Symbol
Cav2
Official Name
caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]
Ensembl ID
ENSMUSG00000000058
Bio databases IDs NCBI: 12390 Ensembl: ENSMUSG00000000058
Aliases caveolin 2
Synonyms CAV, caveolin 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cav2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SNARE binding
  • Caveolin
  • caveolin-scaffolding domain
  • binding protein
  • protein kinase binding
  • G-protein-coupled receptor binding
  • protein binding activity, bridging
  • phosphoprotein binding
  • protein homodimerization
  • protein binding
  • protein heterodimerization
  • syntaxin binding

Pathways

Biological processes and signaling networks where the Cav2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • fibrosis
  • chronic obstructive pulmonary disease
  • acute myeloid leukemia
  • lung adenocarcinoma
  • pancreatic epithelial cancer
  • endometriosis
  • atrial fibrillation
  • open-angle glaucoma
  • cardioembolic stroke
  • peripheral T-cell lymphoma
regulated by
  • 1,1-bis(3'-indolyl)-1-(4-trifluoromethyl-phenyl)methane
  • EGF
  • tetradecanoylphorbol acetate
  • TGFB1
  • dexamethasone
  • TP53
  • HK cells
  • PIM1
  • 15-deoxy-delta-12,14 -PGJ 2
  • TEAD
regulates
  • cyclic AMP
  • ALB
  • TGF beta
  • GP
  • oleic acid
  • CAV1
  • GTPase
role in cell
  • quantity
  • synthesis in
  • proliferation
  • number
  • fusion
  • size
  • formation
  • abnormal morphology
  • assembly
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • plasma membrane fraction
  • raft fractions
  • caveolae fraction
  • detergent-insoluble fractions
  • membrane fraction
  • cilia
  • cell surface
  • perinuclear region
  • cellular membrane
  • focal adhesions
  • vesicles
  • Golgi Apparatus
  • cell-cell contacts
  • lipid droplets
  • caveolar membranes
  • caveola necks
  • caveolae
  • Golgi membrane
  • trans Golgi network
  • inner nuclear membrane
  • nuclear envelope
  • acrosome
  • growth cone
  • transport vesicles
  • cytoplasmic vesicles
  • membrane rafts
  • microvilli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cav2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of dopamine receptor signaling pathway
  • insulin receptor signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • positive regulation of GTPase activity
  • viral entry into host cell via receptor-mediated endocytosis
  • vesicle organization
  • skeletal muscle fiber development
  • negative regulation of skeletal muscle cell proliferation
  • basement membrane organization
  • skeletal muscle cell proliferation
  • caveola assembly
  • regulation of mitosis
  • cytosolic calcium ion homeostasis
  • positive regulation of MAPK cascade
  • endoplasmic reticulum organization
  • mitochondrion organization
  • release of virus from host
  • vesicle fusion
  • vesicle docking
  • cell differentiation
  • endothelial cell proliferation
  • negative regulation of endothelial cell proliferation
  • positive regulation of endothelial cell proliferation
  • negative regulation of transforming growth factor beta receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • acrosomal membrane
  • caveolar macromolecular signaling complex
  • Golgi apparatus
  • Golgi membrane
  • plasma membrane
  • nucleus
  • caveola
  • perinuclear region of cytoplasm
  • focal adhesion
  • sarcolemma
  • membrane raft
  • cytoplasmic vesicle
  • macromolecular complex
  • transport vesicle

Molecular Function

What the gene product does at the molecular level
  • protein kinase binding
  • scaffold protein binding
  • protein homodimerization activity
  • protein binding
  • protein heterodimerization activity
  • protein binding, bridging
  • binding, bridging

Gene-Specific Assays for Results You Can Trust

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