Pemt Gene Summary [Mouse]
Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within blastocyst hatching and sphingomyelin biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; hepatic primordium; liver; lung; and secondary oocyte. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pemt |
| Official Name | phosphatidylethanolamine N-methyltransferase [Source:MGI Symbol;Acc:MGI:104535] |
| Ensembl ID | ENSMUSG00000000301 |
| Bio databases IDs | |
| Aliases | phosphatidylethanolamine N-methyltransferase |
| Synonyms | AI255394, PEAMT, PEMPT, Pempt2, PEMT2, PHOMETH, phosphatidylethanolamine N-methyltransferase, PLMT, PNMT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pemt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylethanolamine binding
- Phospholipid methyltransferase
- enzyme
- protein binding
- S-adenosylmethionine-dependent methyltransferase
- phosphatidylethanolamine N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- weight gain
- obesity
- insulin resistance
- nonalcoholic steatohepatitis
- fibrosis
- insomnia
- whole-body insulin resistance
- hypotrophy
- hepatomegaly
role in cell
- phosphorylation in
- proliferation
- oxidative stress response
- abnormal morphology
- accumulation
- lipotoxicity in
- accumulation in
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- intracellular membrane-bounded organelle
- mitochondrial envelope
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- microsome
- mitochondrial membrane
- mitochondria-associated membranes
- sarcolemma
- brush border
- peroxisomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pemt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blastocyst hatching
- phosphatidylcholine biosynthetic process
- sphingomyelin biosynthetic process
- methylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
- phosphatidylethanolamine N-methyltransferase activity
- phosphatidyl-N-methylethanolamine N-methyltransferase activity