Atg9b Gene Summary [Mouse]
Predicted to enable phospholipid scramblase activity. Predicted to be involved in bone morphogenesis; macroautophagy; and programmed necrotic cell death. Located in autophagosome. Is expressed in brain; future brain; gut; male reproductive gland or organ; and skin. Orthologous to human ATG9B (autophagy related 9B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg9b |
| Official Name | autophagy related 9B [Source:MGI Symbol;Acc:MGI:2685420] |
| Ensembl ID | ENSMUSG00000038295 |
| Bio databases IDs | |
| Aliases | autophagy related 9B |
| Synonyms | Apg912, APG9L2, Apgdc2, autophagy related 9B, eONE, Gm574, LOC105375568, NOS3AS, RGD1560887, SONE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg9b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein ATG9
- phospholipid scramblase
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Atg9b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- organismal death
- premature ovarian failure
- severe combined immunodeficiency
regulates
role in cell
- proliferation
- formation
- autophagy in
- assembly
- self-renewal capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg9b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- programmed necrotic cell death
- piecemeal microautophagy of nucleus
- protein localization to pre-autophagosomal structure
- bone morphogenesis
- phospholipid scrambling
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- trans-Golgi network
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- Golgi membrane
- recycling endosome membrane
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- phospholipid scramblase activity