Mkrn2 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response to antigenic stimulus; negative regulation of non-canonical NF-kappaB signal transduction; and ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mkrn2 |
| Official Name | makorin, ring finger protein, 2 [Source:MGI Symbol;Acc:MGI:1914277] |
| Ensembl ID | ENSMUSG00000000439 |
| Bio databases IDs | |
| Aliases | makorin, ring finger protein, 2 |
| Synonyms | 2610002L04Rik, HSPC070, makorin ring finger protein 2, makorin, ring finger protein, 2, RNF62 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mkrn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- CCCH-type zinc finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mkrn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response to antigenic stimulus
- protein kinase B signaling cascade
- transcription, DNA-dependent
- protein polyubiquitination
- spermatogenesis
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- metal ion binding