Scn4a Gene Summary [Mouse]
Enables voltage-gated sodium channel activity. Acts upstream of or within sodium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart; heart ventricle; and testis. Used to study hyperkalemic periodic paralysis and hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; congenital myopathy 22A; congenital myopathy 22B; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn4a |
| Official Name | sodium channel, voltage-gated, type IV, alpha [Source:MGI Symbol;Acc:MGI:98250] |
| Ensembl ID | ENSMUSG00000001027 |
| Bio databases IDs | |
| Aliases | sodium channel, voltage-gated, type IV, alpha |
| Synonyms | CMS16, CMYO22A, CMYP22A, HOKPP2, HYKPP, hyperkalaemic periodic paralysis, HYPP, mH2, microI, NAC1A, Na(V)1.4, Nav1.4, NCHVS, SKM1, sodium channel, voltage-gated, type IV, alpha, sodium channel, voltage-gated, type IV, α, sodium voltage-gated channel alpha subunit 4, sodium voltage-gated channel α subunit 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scn4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- voltage-gated sodium channel
- voltage sensor segment
- Ion transport protein
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Scn4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- dysmenorrhea
- major depression
- schizophrenia
- bipolar disorder
- hyperkalemic periodic paralysis
- muscle strain
- migraines
- ankle sprain
- paroxysmal atrial fibrillation
regulates
- Na+
- K+
- choline
- cation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scn4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- sodium ion transport
- muscle contraction
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated sodium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- voltage-gated sodium channel activity