Ermp1 Gene Summary [Mouse]
Predicted to enable metal ion binding activity and metalloexopeptidase activity. Predicted to be involved in cellular response to oxidative stress; ovarian follicle development; and proteolysis. Predicted to act upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and sensory organ. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ermp1 |
| Official Name | endoplasmic reticulum metallopeptidase 1 [Source:MGI Symbol;Acc:MGI:106250] |
| Ensembl ID | ENSMUSG00000046324 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum metallopeptidase 1 |
| Synonyms | b2b2633Clo, bA207C16.3, D19Ertd410e, D19Wsu12e, endoplasmic reticulum metallopeptidase 1, FXNA, KIAA1815, mKIAA1815 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ermp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- diabetes mellitus
- idiopathic scoliosis
- acute myeloid leukemia
- allergic asthma
- respiratory disorder
role in cell
- response by
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ermp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- proteolysis
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloexopeptidase activity