Adgre5 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgre5 |
| Official Name | adhesion G protein-coupled receptor E5 [Source:MGI Symbol;Acc:MGI:1347095] |
| Ensembl ID | ENSMUSG00000002885 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor E5 |
| Synonyms | adhesion G protein-coupled receptor E5, CD97, DAF receptor, TM7LN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgre5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- Human growth factor-like EGF
- protein binding
- EGF-receptor binding domain
- seven-transmembrane G protein-coupled receptor superfamily
- EGF-like domain
- glycosaminoglycan binding
- EGF_CA
- binding protein
- stalk region
- GPCR proteolysis site, GPS, motif
- EGF domain
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Adgre5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial neoplasia
- epithelial cancer
- metastasis
- glioblastoma
- psoriasis
- organismal death
- peripheral arterial disease
- uterine leiomyoma
role in cell
- expression in
- proliferation
- migration
- invasion by
- invasion
- recruitment
- binding
- activation in
- penetration
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- secretory granule membrane
- plasma membrane extracellular face
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgre5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- cell-cell signaling
- cell adhesion
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- focal adhesion
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- transmembrane signaling receptor activity
- calcium ion binding