Icam4 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in liver and trigeminal ganglion. Orthologous to human ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icam4 |
| Official Name | intercellular adhesion molecule 4, Landsteiner-Wiener blood group [Source:MGI Symbol;Acc:MGI:1925619] |
| Ensembl ID | ENSMUSG00000001014 |
| Bio databases IDs | |
| Aliases | intercellular adhesion molecule 4, Landsteiner-Wiener blood group |
| Synonyms | 1810015M19Rik, CD242, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group), intercellular adhesion molecule 4, Landsteiner-Wiener blood group, LOC100360240, LW |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Icam4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intercellular adhesion molecule (ICAM), N-terminal domain
- immunoglobulin domain
- integrin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- alveolar soft part sarcoma
- soft tissue sarcoma cancer
role in cell
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Extracellular Space
- cellular membrane
- cytoplasmic aggregates
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Icam4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- integrin binding