Sppl2b Gene Summary [Mouse]
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sppl2b |
| Official Name | signal peptide peptidase like 2B [Source:MGI Symbol;Acc:MGI:1920468] |
| Ensembl ID | ENSMUSG00000035206 |
| Bio databases IDs | |
| Aliases | signal peptide peptidase like 2B |
| Synonyms | 3110056O03Rik, IMP-4, PSH4, PSL1, RGD1308556, signal peptide peptidase-like 2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sppl2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartic endopeptidase, intramembrane cleaving
- PA domain
- PA
- peptidase
- protein homodimerization
- protein binding
- Signal peptide peptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- actin cytoskeleton
- centrosome
- Golgi Apparatus
- Golgi membrane
- lysosome membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sppl2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane protein proteolysis
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- centrosome
- membrane
- Golgi-associated vesicle membrane
- actin cytoskeleton
- endosome membrane
- Golgi membrane
- lysosomal membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- aspartic endopeptidase activity, intramembrane cleaving