Tnp2 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in positive regulation of protein processing and sperm DNA condensation. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; flagellated sperm motility; and penetration of zona pellucida. Located in male germ cell nucleus. Part of nucleosome. Is expressed in spermatid and testis. Orthologous to human TNP2 (transition protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnp2 |
| Official Name | transition protein 2 [Source:MGI Symbol;Acc:MGI:98785] |
| Ensembl ID | ENSMUSG00000043050 |
| Bio databases IDs | |
| Aliases | transition protein 2 |
| Synonyms | TP2, transition protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- Nuclear transition protein 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- asthenozoospermia
- teratozoospermia
regulates
role in cell
- formation
- binding
- abnormal morphology
- condensation
- morphology
- motility
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoli
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome reaction
- penetration of zona pellucida
- spermatogenesis
- sperm chromatin condensation
- positive regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- nucleosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding