Pbxip1 Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within several processes, including articular cartilage development; extracellular matrix organization; and positive regulation of chondrocyte proliferation. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in brain; diaphragm; gut; heart ventricle; and spinal cord ventricular layer. Orthologous to human PBXIP1 (PBX homeobox interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pbxip1 |
| Official Name | pre B cell leukemia transcription factor interacting protein 1 [Source:MGI Symbol;Acc:MGI:2441670] |
| Ensembl ID | ENSMUSG00000042613 |
| Bio databases IDs | |
| Aliases | pre B cell leukemia transcription factor interacting protein 1 |
| Synonyms | 4732463H20Rik, HPIP, MGC38361, PBX homeobox interacting protein 1, pre B cell leukaemia transcription factor interacting protein 1, pre B cell leukemia transcription factor interacting protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pbxip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription co-repressor
- transcription factor binding
- protein binding
- Cell division protein ZapB
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardioembolic stroke
- Parkinson disease
role in cell
- proliferation
- colony formation
- differentiation
- quantity
- adhesion
- accumulation
- disassembly
- ubiquitination in
- activation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pbxip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- production of molecular mediator involved in inflammatory response
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- hemopoiesis
- extracellular matrix disassembly
- regulation of Rho guanyl-nucleotide exchange factor activity
- cell adhesion
- positive regulation of Wnt receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- membrane
- cytosol
- chromatin
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- transcription corepressor activity