Trim38 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of defense response to virus; positive regulation of viral genome replication; and protein K48-linked ubiquitination. Predicted to be active in cytoplasm. Orthologous to human TRIM38 (tripartite motif containing 38). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim38 |
| Official Name | tripartite motif-containing 38 [Source:MGI Symbol;Acc:MGI:2684869] |
| Ensembl ID | ENSMUSG00000064140 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 38 |
| Synonyms | Gm23, RNF15, RORET, tripartite motif-containing 38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription co-activator
- B-Box C-terminal domain
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ocular hypertension
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- nonalcoholic fatty liver disease
- hepatic steatosis
- hepatitis
- lung cancer
- non-small cell lung cancer
- inguinal hernia
role in cell
- replication in
- production in
- expression in
- activation in
- signaling in
- degradation in
- K48 polyubiquitination in
- transcription in
- transactivation in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- regulation of protein localization
- protein sumoylation
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of viral entry into host cell
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of autophagy
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of interferon-beta production
- regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of viral genome replication
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein binding
- protein homodimerization activity
- transcription coactivator activity