Ptpn7 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Is expressed in liver and thymus primordium. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn7 |
| Official Name | protein tyrosine phosphatase, non-receptor type 7 [Source:MGI Symbol;Acc:MGI:2156893] |
| Ensembl ID | ENSMUSG00000031506 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 7 |
| Synonyms | BPTP-4, C920001D21RIK, HEPTP, LC-PTP, LPTP, protein tyrosine phosphatase non-receptor type 7, protein tyrosine phosphatase, non-receptor type 7, PTPNI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- non-membrane spanning protein tyrosine phosphatase
- kinase interacting domain
- protein-tyrosine-phoshatase
- phosphatase
- active site
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Ptpn7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic epithelial cancer
- chronic lymphocytic leukemia
- androgenic alopecia
- pancreatic adenocarcinoma
role in cell
- phosphorylation in
- survival
- phagocytosis by
- development
- aggregation
- phagocytosis
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- membrane rafts
- mitotic spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- mitotic spindle
- cytoplasm
- cytosol
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity