Meox1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sclerotome development. Acts upstream of or within somite specification. Located in cytoplasm and nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; limb; and musculoskeletal system. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meox1 |
| Official Name | mesenchyme homeobox 1 [Source:MGI Symbol;Acc:MGI:103220] |
| Ensembl ID | ENSMUSG00000001493 |
| Bio databases IDs | |
| Aliases | mesenchyme homeobox 1 |
| Synonyms | D330041M02Rik, KFS2, mesenchyme homeobox 1, MOX1, squig |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Meox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- hemivertebra
- congenital malformation
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Klippel-Feil syndrome type 2
- cyanosis
- androgenic alopecia
- diabetic nephropathy
- Wilms tumor
role in cell
- expression in
- proliferation
- activation in
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Meox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sclerotome development
- somite development
- somite specification
- hemopoietic stem cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- HMG box domain binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity