Nkx3-2 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of chondrocyte differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including intestinal epithelial cell development; middle ear morphogenesis; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human NKX3-2 (NK3 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx3-2 |
| Official Name | NK3 homeobox 2 [Source:MGI Symbol;Acc:MGI:108015] |
| Ensembl ID | ENSMUSG00000049691 |
| Bio databases IDs | |
| Aliases | NK3 homeobox 2 |
| Synonyms | BAPX1, NK3 homeobox 2, NKX3.2, NKX3B, SMMD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkx3-2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Nkx3-2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hypoplasia
- spondylo-megaepiphyseal-metaphyseal dysplasia
- organismal death
- connective tissue disorder
- dysplasia
role in cell
- activation in
- apoptosis
- differentiation
- development
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkx3-2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- middle ear morphogenesis
- transcription from RNA polymerase II promoter
- spleen development
- organ formation
- intestinal epithelial cell development
- embryonic skeletal system development
- skeletal system morphogenesis
- determination of left/right symmetry
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- skeletal system development
- negative regulation of apoptotic process
- cell differentiation
- negative regulation of chondrocyte differentiation
- pancreas development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity