MEOX1 Gene Summary [Human]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MEOX1 |
| Official Name | mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013] |
| Ensembl ID | ENSG00000005102 |
| Bio databases IDs | |
| Aliases | mesenchyme homeobox 1 |
| Synonyms | D330041M02Rik, KFS2, mesenchyme homeobox 1, MOX1, squig |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEOX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- hemivertebra
- congenital malformation
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Klippel-Feil syndrome type 2
- cyanosis
- androgenic alopecia
- diabetic nephropathy
- Wilms tumor
role in cell
- expression in
- proliferation
- activation in
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEOX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sclerotome development
- somite development
- somite specification
- hemopoietic stem cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- HMG box domain binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity