En2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic brain development and negative regulation of neuron apoptotic process. Acts upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; gut; and limb bud. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | En2 |
| Official Name | engrailed 2 [Source:MGI Symbol;Acc:MGI:95390] |
| Ensembl ID | ENSMUSG00000039095 |
| Bio databases IDs | |
| Aliases | engrailed 2 |
| Synonyms | AUTS1, BB131122, engrailed 2, engrailed homeobox 2, mo-En-2, RGD1561842 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse En2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- transcription repression domain
- nucleic acid binding
- double-stranded DNA binding
- transcription co-repressor
- transcription factor binding
- Engrailed homeobox C-terminal signature domain
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- complex neurodevelopmental disorder
- motor dysfunction or movement disorder
role in cell
- apoptosis
- differentiation
- cell death
- quantity
- development
- survival
- generation
- targeting
- commitment
- cardiomyogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse En2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- midbrain development
- hindbrain development
- dopaminergic neuron differentiation
- neuron differentiation
- neuron development
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity