Appl1 Gene Summary [Mouse]
Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of cytokine production involved in inflammatory response; and regulation of endocytosis. Located in cytoplasmic vesicle and ruffle. Is expressed in several structures, including liver; muscle tissue; spleen; stomach; and testis. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Appl1 |
| Official Name | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 [Source:MGI Symbol;Acc:MGI:1920243] |
| Ensembl ID | ENSMUSG00000040760 |
| Bio databases IDs | |
| Aliases | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 |
| Synonyms | 2900057D21RIK, 7330406P05Rik, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1, APPL, APPL1 (MODY14), DIP13, DIP13alpha, MODY14, RGD1309388, SWI/SNF RELATED REGULATOR SUBFAMILY C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Appl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- phospholipid binding
- protein kinase binding
- coiled-coil domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- BAR domain of APPL family
- binding protein
- Dcc binding domain
- PH domain
- protein homodimerization
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Appl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- impaired glucose tolerance
- maturity-onset diabetes of the young type 14
- non-small cell lung cancer
- glucocorticoid induced osteoporosis
- major depression
- osteoporosis
- monogenic diabetes
role in cell
- cell viability
- expression in
- apoptosis
- activation in
- cell death
- phosphorylation in
- damage
- proliferation
- production in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- ruffle
- presynaptic regions
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- cytosol
- vesicle membrane
- membrane ruffles
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- light microsome fraction
- phagosomes
- macropinosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Appl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- insulin receptor signaling pathway
- regulation of toll-like receptor 4 signaling pathway
- transforming growth factor beta receptor signaling pathway
- positive regulation of glucose import
- regulation of glucose import
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of melanin biosynthetic process
- protein import into nucleus
- cellular response to hepatocyte growth factor stimulus
- signaling
- regulation of innate immune response
- regulation of G1/S transition of mitotic cell cycle
- adiponectin-mediated signaling pathway
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- macropinosome
- plasma membrane
- early endosome membrane
- nucleus
- early endosome
- early phagosome
- endosome
- extracellular vesicular exosome
- cytoplasm
- vesicle membrane
- membrane
- ruffle
- cytosol
- cytoplasmic vesicle
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- phosphatidylserine binding
- protein homodimerization activity
- protein binding
- beta-tubulin binding
- phosphatidylinositol binding
- protein kinase B binding