Tcirg1 Gene Summary [Mouse]
Predicted to enable ATPase binding activity. Acts upstream of or within several processes, including T cell activation; odontogenesis; and regulation of pH. Located in several cellular components, including cytoplasmic vesicle; lysosome; and nucleus. Is expressed in several structures, including ciliary body; future brain; hemolymphoid system gland; metanephros; and optic choroid plus pigmented retinal epithelium. Used to study autosomal recessive osteopetrosis 1 and clubfoot. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1. Orthologous to human TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tcirg1 |
| Official Name | T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 [Source:MGI Symbol;Acc:MGI:1350931] |
| Ensembl ID | ENSMUSG00000001750 |
| Bio databases IDs | |
| Aliases | T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 |
| Synonyms | a3, ATP6a3, Atp6i, ATP6N1C, ATP6V0A3, oc, OC-116, OC-116kDa, OPTB1, osteoclast V-H+ ATPase 100-kd transmembrane subunit, Stv1, T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3, T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3, TIRC7, V-ATPase subunit a3, Vph1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcirg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen-transporting ATPase activity, rotational mechanism
- enzyme
- protein binding
- V-type ATPase 116kDa subunit family
Pathways
Biological processes and signaling networks where the Tcirg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive osteopetrosis type 1
- androgenic alopecia
- rheumatoid arthritis
- hypersensitive reaction
- choreaacanthocytosis
- autosomal recessive osteopetrosis
- hyperplasia
- collagen-induced arthritis
- growth failure
- hereditary disorder
role in cell
- apoptosis
- differentiation
- quantity
- proliferation
- cellular infiltration by
- activation
- function
- number
- degradation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Cytoplasm
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- filamentous network
- Nucleus
- lysosome
- secretory granule membrane
- membrane ruffles
- apical membrane
- endosome-lysosome compartments
- lysosome membrane
- endosomal membrane
- late endosomes
- brush border
- cell membrane leading edge
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcirg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- positive regulation of cell proliferation
- vacuolar acidification
- regulation of osteoblast differentiation
- T cell homeostasis
- optic nerve development
- vacuolar protein catabolic process
- osteoclast proliferation
- autophagic vacuole assembly
- dentin mineralization
- regulation of insulin secretion
- inflammatory response
- enamel mineralization
- bone resorption
- ossification
- apoptotic process
- regulation of proton transport
- macroautophagy
- T-helper 1 cell activation
- response to silver ion
- B cell differentiation
- lysosomal lumen acidification
- phagosome acidification
- pH reduction
- cellular calcium ion homeostasis
- T cell differentiation
- osteoclast differentiation
- memory T cell activation
- cellular defense response
- establishment of vesicle localization
- ruffle organization
- immunoglobulin mediated immune response
- regulation of gene expression
- gene expression
- establishment of cell polarity
- cellular response to cytokine stimulus
- protein localization to organelle
Cellular Component
Where in the cell the gene product is active
- nucleus
- vacuolar proton-transporting V-type ATPase, V0 domain
- proton-transporting V-type ATPase complex
- vacuolar proton-transporting V-type ATPase complex
- late endosome
- phagocytic vesicle membrane
- endosome membrane
- lysosomal membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- ATPase binding