Ppp1r15b Gene Summary [Mouse]
Enables protein phosphatase regulator activity. Acts upstream of or within ER overload response and response to hydrogen peroxide. Part of protein phosphatase type 1 complex. Is expressed in compacted morula and inner cell mass. Orthologous to human PPP1R15B (protein phosphatase 1 regulatory subunit 15B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r15b |
| Official Name | protein phosphatase 1, regulatory subunit 15B [Source:MGI Symbol;Acc:MGI:2444211] |
| Ensembl ID | ENSMUSG00000046062 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 15B |
| Synonyms | 1810033K10Rik, C530022L24Rik, CREP, MSSGM2, protein phosphatase 1 regulatory subunit 15B, protein phosphatase 1, regulatory subunit 15B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r15b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eIF2-alpha phosphatase phosphorylation constitutive repressor
- phosphatase
- protein phosphatase regulator
- Phosphatase-1 catalytic subunit binding region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- echinocytosis
- microcephaly, short stature, and impaired glucose metabolism type 2
- infection by vesicular stomatitis virus
role in cell
- expression in
- number
- cell death
- induction in
- translation in
- abnormal morphology
- josamycin sensitivity
- integrated stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r15b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- positive regulation of phosphoprotein phosphatase activity
- negative regulation of protein phosphorylation
- response to hydrogen peroxide
- ER overload response
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- protein phosphatase type 1 complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity