Atp6v1c1 Gene Summary [Mouse]
Enables proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in plasma membrane. Part of proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1c1 |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit C1 [Source:MGI Symbol;Acc:MGI:1913585] |
| Ensembl ID | ENSMUSG00000022295 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit C1 |
| Synonyms | 1700025B18Rik, ATP6C, ATP6D, ATPase, H+ transporting, lysosomal V1 subunit C1, ATPase H+ transporting V1 subunit C1, VATC, V-ATPase V1-C1, Vma5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- transporter
- Subunit C of vacuolar H+-ATPase (V-ATPase)
Pathways
Biological processes and signaling networks where the Atp6v1c1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- septic shock
- neonatal late-onset sepsis
- deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome
- obstructive sleep apnea
regulates
- ATP6V1C1
- H+
role in cell
- migration
- acidification in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apical compartment
- cellular membrane
- Plasma Membrane
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- proton-transporting two-sector ATPase complex
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- apical part of cell
- cytosol
- plasma membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism