Folh1 Gene Summary [Mouse]
Enables carboxypeptidase activity and dipeptidase activity. Acts upstream of or within folic acid-containing compound metabolic process and proteolysis. Located in plasma membrane. Is expressed in central nervous system; male reproductive gland or organ; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Folh1 |
| Official Name | folate hydrolase 1 [Source:MGI Symbol;Acc:MGI:1858193] |
| Ensembl ID | ENSMUSG00000001773 |
| Bio databases IDs | |
| Aliases | folate hydrolase 1 |
| Synonyms | FGCP, folate hydrolase 1, FOLH, GCP2, GCPII, mGCP, mopsm, Naalad, NAALAD1, NAALADase I, PSM, PSMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Folh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- carboxypeptidase
- dipeptidase
- ectodomain
- peptidase
- metallocarboxypeptidase
- protein binding
- Peptidase family M28
- PA domain
- binding protein
- PA
- Transferrin receptor-like dimerization domain
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- metastatic castration resistant prostate adenocarcinoma
- hormone dependent prostate cancer
- salivary duct carcinoma
- salivary duct cancer
- glioblastoma
- glioblastoma cancer
- schizophrenia
role in cell
- phosphorylation in
- apoptosis
- invasion
- invasiveness
- binding
- degeneration
- invasion by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- recycling endosomes
- cytoplasmic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Folh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- C-terminal protein deglutamylation
- folic acid-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- metallocarboxypeptidase activity
- metal ion binding
- dipeptidase activity
- peptidase activity