Ift46 Gene Summary [Mouse]
Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in centrosome and motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; hindlimb; and otocyst. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ift46 |
| Official Name | intraflagellar transport 46 [Source:MGI Symbol;Acc:MGI:1923818] |
| Ensembl ID | ENSMUSG00000002031 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 46 |
| Synonyms | 1500035H01Rik, C11orf2, C11orf60, CFAP32, FAP32, intraflagellar transport 46, RGD1307682 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ift46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intraflagellar transport complex B protein 46 C terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary tip
- cilia
- basal bodies
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ift46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intraflagellar transport
- cilium morphogenesis
- protein stabilization
- intraflagellar anterograde transport
Cellular Component
Where in the cell the gene product is active
- motile cilium
- centrosome
- cilium basal body
- cytoplasm
- cilium
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- protein binding