Cacna2d2 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within several processes, including neuromuscular junction development; positive regulation of organ growth; and rhythmic synaptic transmission. Part of voltage-gated calcium channel complex. Is active in GABA-ergic synapse and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; lip; and retina. Used to study epilepsy and generalized epilepsy. Orthologous to human CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna2d2 |
| Official Name | calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813] |
| Ensembl ID | ENSMUSG00000010066 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
| Synonyms | a2d2, CACNA2D, calcium channel, voltage-dependent, alpha 2/delta subunit 2, calcium channel, voltage-dependent, α 2/δ subunit 2, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD, du, mKIAA0558, td, torpid |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacna2d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Neuronal voltage-dependent calcium channel alpha 2acd
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- Sensor domains of Histidine Kinase receptors
- VWA N-terminal
- ion channel
- calcium channel regulator
Pathways
Biological processes and signaling networks where the Cacna2d2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Estrogen Receptor Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Mitochondrial Dysfunction
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- cancer
- hypertension
- diabetes mellitus
- schizophrenia
- dry eye
- asthma
- HIV infection
- bipolar disorder
- alcoholism
phenotypes
- Purkinje cell degeneration
- abnormal CNS glial cell morphology
- abnormal CNS synaptic transmission
- abnormal Purkinje cell morphology
- abnormal axon morphology
- abnormal brain wave pattern
- abnormal cerebellum morphology
- abnormal dorsal spinal root morphology
- abnormal eating behavior
- abnormal enzyme/coenzyme activity
- abnormal gait
- abnormal glial cell physiology
- abnormal heart rate
- abnormal hindbrain development
- abnormal hindbrain morphology
- abnormal involuntary movement
- abnormal locomotor behavior
- abnormal medulla oblongata morphology
- abnormal miniature endplate potential
- abnormal miniature inhibitory postsynaptic currents
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal motor neuron morphology
- abnormal myelination
- abnormal nervous system electrophysiology
- abnormal neuromuscular synapse morphology
- abnormal neuron morphology
- abnormal neuron physiology
- abnormal pituitary gland morphology
- abnormal sexual interaction
- abnormal spike wave discharge
- abnormal spinal cord morphology
- abnormal spinal cord white matter morphology
- abnormal spinal nerve morphology
- abnormal stationary movement
- abnormal thymus involution
- abnormal uterus morphology
- abnormal ventral spinal root morphology
- abnormal vertebral column morphology
- absence seizures
- absent corpus luteum
- absent lactotrophs
- ataxia
- axonal dystrophy
- behavioral arrest
- cerebellum vermis hypoplasia
- decreased Purkinje cell number
- decreased body size
- decreased body weight
- decreased brain weight
- decreased heart rate
- decreased neuron number
- decreased neurotransmitter release
- decreased pons size
- decreased spinal cord size
- decreased survivor rate
- dehydration
- female infertility
- hindlimb paralysis
- impaired coordination
- increased susceptibility to pharmacologically induced seizures
- induced hyperactivity
- lethargy
- limb grasping
- myoclonus
- no abnormal phenotype detected
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- reduced female fertility
- reduced fertility
- reduced male fertility
- rhinitis
- seizures
- short vertebral body
- skeletal muscle hypoplasia
- small cerebellum
- thymus hypoplasia
- tonic seizures
- tremors
role in cell
- apoptosis
- growth
- quantity
- development
- morphology
- degeneration
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacna2d2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- organ growth
- regulation of multicellular organism growth
- rhythmic synaptic transmission
- muscle cell development
- calcium ion transmembrane transport
- positive regulation of organ growth
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- voltage-gated calcium channel activity