Man2a2 Gene Summary [Mouse]
Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to be active in Golgi membrane. Is expressed in olfactory epithelium; retina outer nuclear layer; skeletal muscle; and vomeronasal organ. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Man2a2 |
| Official Name | mannosidase 2, alpha 2 [Source:MGI Symbol;Acc:MGI:2150656] |
| Ensembl ID | ENSMUSG00000038886 |
| Bio databases IDs | |
| Aliases | mannosidase 2, alpha 2 |
| Synonyms | 1700052O22RIK, 4931438M07Rik, alpha-MIIx, MANA2X, MAN IIx, mannosidase 2, alpha 2, mannosidase 2, α 2, mannosidase alpha class 2A member 2, mannosidase, alpha, class 2A, member 2, mannosidase α class 2A member 2, mannosidase, α, class 2A, member 2, MX, α-MIIx |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 38 N-terminal domain
- Alpha mannosidase middle domain
- mannosidase
- GH38-57_N_LamB_YdjC_SF
- N-glycosyl glycosylase
- Alpha mannosidase, middle domain
- Glycosyl hydrolases family 38 C-terminal domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oligozoospermia
- respiratory failure
- attention deficit hyperactivity disorder
- endometriosis
regulates
- mannosidase alpha
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deglycosylation
- N-glycan processing
- protein glycosylation
- mannose metabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, hydrolyzing N-glycosyl compounds
- alpha-mannosidase activity
- metal ion binding
- mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
- carbohydrate binding