Rgs19 Gene Summary [Mouse]
Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in brush border and clathrin-coated vesicle. Is expressed in embryo; forelimb bud; palatal shelf epithelium; and primary palate epithelium. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs19 |
| Official Name | regulator of G-protein signaling 19 [Source:MGI Symbol;Acc:MGI:1915153] |
| Ensembl ID | ENSMUSG00000002458 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 19 |
| Synonyms | 2610042F04Rik, Camki, GAIP, G-α-interacting, regulator of G-protein signaling 19, RGSGAIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- myosin binding
- actin binding
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- Cysteine string motif
- identical protein binding
Pathways
Biological processes and signaling networks where the Rgs19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- chronic kidney disease
- peptic ulcer disease
- ventricular septal defect
role in cell
- expression in
- proliferation
- maturation
- differentiation
- autophagy
- macroautophagy
- signaling in
- repolarization
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- intracellular membranes
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- vesicle membrane
- microsome
- sinusoidal membrane
- Golgi membrane
- dendritic spines
- synaptic vesicles
- synapse
- cytoplasmic vesicles
- brush border
- clathrin-coated pits
- dendritic shafts
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- small GTPase mediated signal transduction
- autophagy
Cellular Component
Where in the cell the gene product is active
- brush border
- membrane
- Golgi apparatus
- clathrin-coated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein alpha-subunit binding
- GTPase activity