Gnao1 Gene Summary [Mouse]
Enables G protein activity and GTP binding activity. Involved in negative regulation of insulin secretion and postsynaptic modulation of chemical synaptic transmission. Acts upstream of with a negative effect on vesicle docking involved in exocytosis. Acts upstream of or within G protein-coupled dopamine receptor signaling pathway; locomotory behavior; and regulation of heart contraction. Located in cell body and dendrite. Is active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnao1 |
| Official Name | guanine nucleotide binding protein, alpha O [Source:MGI Symbol;Acc:MGI:95775] |
| Ensembl ID | ENSMUSG00000031748 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein, alpha O |
| Synonyms | alphaO, AW050213, DEE17, EIEE17, G-ALPHA-o, GAO2, GNAO, GNAO2, Go, Go2 α, Go alpha subunit 2, Go α, Go α subunit 2, G protein alpha O subunit, G protein ao, G protein O, G protein subunit alpha o1, G protein subunit α o1, G-protein α o, G protein α o1, G protein α O subunit, guanine nucleotide binding protein, alpha O, guanine nucleotide binding protein, α O, G zero, G α-O, HG1G, HLA-DQB1, NEDIM, RATBPGTPC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnao1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- small monomeric GTPase
- G-protein-coupled receptor binding
- GTPase
- enzyme
- enzyme regulator activity
- protein binding
- receptor binding
- GTP binding
- ADP-ribosylation domain
- GTPase domain
- GDP binding
- G-protein alpha subunit
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Gnao1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- GABA Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- IL-8 Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Relaxin Signaling
- RhoGDI Signaling
- Thrombin Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- neoplasia
- cancer
- neoplastic cell transformation
- insomnia
- Ohtahara syndrome
- choreoathetosis
- early infantile epileptic encephalopathy type 17
- neurodevelopmental disorder with involuntary movements
- hereditary disorder
role in cell
- cell death
- expression in
- phosphorylation in
- apoptosis
- proliferation
- differentiation
- activation in
- colony formation
- molecular cleavage in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- plasma membrane fraction
- myelin enriched fraction
- detergent-soluble membrane fractions
- membrane fraction
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- glutaminergic synapse
- perimembrane region
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Golgi Apparatus
- cytosol
- vesicle membrane
- caveolar membranes
- presynaptic membrane
- postsynaptic membrane
- synaptic vesicles
- growth cone
- myelin sheath
- synapse
- dense-core vesicles
- transverse tubules
- perikaryon
- axons
- dendrites
- excitatory synapses
- clathrin-coated vesicles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnao1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- muscle contraction
- vesicle docking involved in exocytosis
- dopamine receptor signaling pathway
- regulation of heart contraction
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- negative regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- dendrite
- heterotrimeric G-protein complex
- cytoplasm
- cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- corticotropin-releasing hormone receptor 1 binding
- GTPase activity
- G-protein beta/gamma-subunit complex binding
- G-protein coupled serotonin receptor binding
- mu-type opioid receptor binding