Nppb Gene Summary [Mouse]
This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | Nppb |
| Official Name | natriuretic peptide type B [Source:MGI Symbol;Acc:MGI:97368] |
| Ensembl ID | ENSMUSG00000029019 |
| Bio databases IDs | |
| Aliases | natriuretic peptide type B |
| Synonyms | BNF, BNP, Brain natriuretic peptide, Iso-ANP, Natriuretic factor, natriuretic peptide B, natriuretic peptide type B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nppb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Atrial natriuretic peptide
- diuretic hormone
- hormone
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Nppb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- stroke
- hepatic fibrosis
- early-onset preeclampsia
- organismal death
- left ventricular hypertrophy
- proteinuria
- septic shock
- acute respiratory distress syndrome
- pancreatic ductal adenocarcinoma
role in cell
- apoptosis
- growth
- binding
- activation
- expression in
- inhibition
- chemotaxis
- proliferation
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- perinuclear region
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nppb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- cGMP biosynthetic process
- cGMP-mediated signaling
- cardiac conduction system development
- negative regulation of systemic arterial blood pressure
- receptor guanylyl cyclase signaling pathway
- cell surface receptor signaling pathway
- regulation of vascular permeability
- vasodilation
- protein folding
- regulation of blood pressure
- body fluid secretion
- neuropeptide signaling pathway
- positive regulation of renal sodium excretion
- negative regulation of cell growth
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- macromolecular complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity
- hormone receptor binding
- diuretic hormone activity
- receptor binding