Mzt1 Gene Summary [Mouse]

Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be located in cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Is expressed in several structures, including central nervous system; primary oocyte; and retina. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Mzt1
Official Name
mitotic spindle organizing protein 1 [Source:MGI Symbol;Acc:MGI:1924039]
Ensembl ID
ENSMUSG00000033186
Bio databases IDs NCBI: 76789 Ensembl: ENSMUSG00000033186
Aliases mitotic spindle organizing protein 1
Synonyms 2410129H14Rik, C13orf37, FLJ21869, mitotic spindle organizing protein 1, MOZART1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mzt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mitotic-spindle organizing gamma-tubulin ring associated
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • severe acute respiratory syndrome
regulated by
  • T lymphocytes

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • spindle apparatus
  • centrosome
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mzt1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • gamma-tubulin complex localization
  • interphase microtubule nucleation by interphase microtubule organizing center
  • spindle assembly involved in mitosis

Cellular Component

Where in the cell the gene product is active
  • centrosome
  • interphase microtubule organizing center
  • spindle
  • cytosol
  • gamma-tubulin large complex
  • gamma-tubulin complex

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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