Rc3h2 Gene Summary [Mouse]
Enables mRNA binding activity. Involved in T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; and regulation of miRNA metabolic process. Acts upstream of or within several processes, including T cell activation; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rc3h2 |
| Official Name | ring finger and CCCH-type zinc finger domains 2 [Source:MGI Symbol;Acc:MGI:2442789] |
| Ensembl ID | ENSMUSG00000075376 |
| Bio databases IDs | |
| Aliases | ring finger and CCCH-type zinc finger domains 2 |
| Synonyms | 2900024N03RIK, 9430019J22Rik, D930043C02Rik, MNAB, ring finger and CCCH-type domains 2, ring finger and CCCH-type zinc finger domains 2, RNF164, Roquin-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rc3h2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- DNA binding
- RNA binding
- zinc finger
- Roquin II domain
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- double-stranded RNA binding
- zinc finger domain
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- insomnia
- organismal death
- suicide attempt
role in cell
- expression in
- proliferation
- number
- quantity
- production in
- differentiation
- upregulation in
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rc3h2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- limb development
- protein polyubiquitination
- post-embryonic development
- spleen development
- lymph node development
- B cell homeostasis
- T cell homeostasis
- ubiquitin-dependent protein catabolic process
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- regulation of miRNA metabolic process
- lung alveolus development
- T cell proliferation
- negative regulation of T-helper 17 cell differentiation
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- intracellular membrane-bounded organelle
- membrane
- cytoplasmic mRNA processing body
- cell surface
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- double-stranded RNA binding
- metal ion binding
- RNA stem-loop binding
- mRNA binding