Plekha3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; genitourinary system; orbito-sphenoid; and vascular system. Orthologous to human PLEKHA3 (pleckstrin homology domain containing A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekha3 |
| Official Name | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 [Source:MGI Symbol;Acc:MGI:1932515] |
| Ensembl ID | ENSMUSG00000002733 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 |
| Synonyms | FAPP1, pleckstrin homology domain containing A3, pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekha3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Plekha3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekha3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- retrograde transport, endosome to Golgi
- receptor recycling
Cellular Component
Where in the cell the gene product is active
- early endosome
- trans-Golgi network
- cytosol
- Golgi membrane
- recycling endosome
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- identical protein binding
- protein binding