Itgb7 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Acts upstream of or within T cell migration. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Is expressed in genitourinary system and thymus primordium. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgb7 |
| Official Name | integrin beta 7 [Source:MGI Symbol;Acc:MGI:96616] |
| Ensembl ID | ENSMUSG00000001281 |
| Bio databases IDs | |
| Aliases | integrin beta 7 |
| Synonyms | CD103 beta, CD103 β, integrin beta 7, integrin subunit beta 7, integrin subunit β 7, Integrin β 7, Ly69 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgb7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIDAS motif
- Integrin beta chain VWA domain
- extracellular domain
- Plexin repeat
- Integrin plexin domain
- cell adhesion molecule binding
- protein binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- EGF_CA
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- cytoplasmic domain
- vWFA
- cytosolic tail domain
- transmembrane receptor
- Integrin beta epidermal growth factor like domain 1
Pathways
Biological processes and signaling networks where the Itgb7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- ILK Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- diarrhea
- cancer
- eosinophilia
- systemic lupus erythematosus
- septic shock
- ulcerative colitis
- moderately to severely active Crohn disease
- Crohn disease
- refractory Crohn disease
role in cell
- activation in
- migration
- induction
- binding
- degranulation
- production in
- recruitment
- quantity
- number
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgb7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- viral entry into host cell
- cell adhesion
- receptor clustering
- immune response in gut-associated lymphoid tissue
- cell-matrix adhesion involved in ameboidal cell migration
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- T cell migration
- leukocyte migration
- leukocyte tethering or rolling
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- membrane
- receptor complex
- integrin complex
- alpha4-beta7 integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cell adhesion molecule binding
- viral receptor activity
- integrin binding