Sptbn2 Gene Summary [Mouse]
A structural constituent of postsynapse. Involved in postsynapse organization and regulation of postsynaptic specialization assembly. Acts upstream of or within adult behavior; cerebellar Purkinje cell layer morphogenesis; and synapse assembly. Located in apical plasma membrane and neuronal cell body. Is active in several cellular components, including parallel fiber to Purkinje cell synapse; paranodal junction; and postsynaptic spectrin-associated cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skin. Used to study spinocerebellar ataxia type 5. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sptbn2 |
| Official Name | spectrin beta, non-erythrocytic 2 [Source:MGI Symbol;Acc:MGI:1313261] |
| Ensembl ID | ENSMUSG00000067889 |
| Bio databases IDs | |
| Aliases | spectrin beta, non-erythrocytic 2 |
| Synonyms | beta 3 SPECTRIN, beta III Spectrin, GTRAP41, LOC105369445, SCA5, SCAR14, Spectrin beta III, spectrin beta, non-erythrocytic 2, spectrin, beta, non-erythrocytic 2, Spectrin β III, spectrin β, non-erythrocytic 2, spectrin, β, non-erythrocytic 2, SPNB3, β 3 SPECTRIN, β III Spectrin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sptbn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- SPEC
- exonuclease SbcC
- Calponin homology domain
- membrane-association domain
- protein binding
- Pleckstrin homology-like domain
- chromosome segregation protein SMC, common bacterial type
- Spectrin repeats
- actin-binding domain
- structural constituent of cytoskeleton
- actin binding
- Spectrin repeat
- PH domain
- calponin homology (CH) domain superfamily
- structural molecule
- golgi targeting sequence
Pathways
Biological processes and signaling networks where the Sptbn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rectum cancer
- colorectal cancer
- ataxia
- spinocerebellar ataxia type 5
- major depression
- autosomal recessive spinocerebellar ataxia type 14
- osteoarthritis
- hereditary disorder
- opioid dependence
- breast carcinoma
role in cell
- quantity
- accumulation in
- cell viability
- density
- migration
- binding in
- assembly
- diameter
- erastin sensitivity
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- Golgi-enriched fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cytoskeleton
- presynaptic regions
- cell surface
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- apical membrane
- lateral plasma membrane
- Golgi membrane
- trans face of the Golgi apparatus
- nucleoli
- nuclear scaffolds
- nuclear matrix
- dendritic spines
- dendritic spine neck
- synaptic vesicles
- paranodal junctions
- dendritic trees
- photoreceptor inner segments
- I band
- perikaryon
- dendrites
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sptbn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- synapse assembly
- cerebellar Purkinje cell layer morphogenesis
- vesicle-mediated transport
- actin filament capping
- actin cytoskeleton organization
- adult behavior
Cellular Component
Where in the cell the gene product is active
- extracellular space
- paranodal junction
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- neuronal cell body
- cell projection
- spectrin
- plasma membrane
- cortical actin cytoskeleton
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- actin binding
- cadherin binding
- structural constituent of cytoskeleton
- phospholipid binding