Bcl2l12 Gene Summary [Mouse]
Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l12 |
| Official Name | BCL2-like 12 (proline rich) [Source:MGI Symbol;Acc:MGI:1922986] |
| Ensembl ID | ENSMUSG00000003190 |
| Bio databases IDs | |
| Aliases | BCL2-like 12 (proline rich) |
| Synonyms | 2810475P17Rik, 5430429M05Rik, BCL2 like 12, Bcl-L12, BPR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2l12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial basal cell carcinoma
- epithelial cancer
- skin neoplasm
- skin neoplasia
- melanoma
- melanoma cancer
- ulcerative colitis
- inflammatory bowel disease
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- binding in
- activation in
- apoptosis
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2l12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of extrinsic apoptotic signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane