Gatb Gene Summary [Mouse]
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gatb |
| Official Name | glutamyl-tRNA(Gln) amidotransferase, subunit B [Source:MGI Symbol;Acc:MGI:2442496] |
| Ensembl ID | ENSMUSG00000028085 |
| Bio databases IDs | |
| Aliases | glutamyl-tRNA(Gln) amidotransferase, subunit B |
| Synonyms | 9430026F02Rik, COXPD41, glutamyl-tRNA amidotransferase subunit B, HSPC199, PET112, PET112L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gatb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GatB/GatE catalytic domain
- GatB domain
- glutaminyl-tRNA synthase (glutamine-hydrolysing)
- aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit
- enzyme
- protein binding
- glutaminyl-tRNA synthase (glutamine-hydrolyzing)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gatb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutaminyl-tRNAGln biosynthesis via transamidation
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- glutamyl-tRNA(Gln) amidotransferase complex
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity