Ncam1 Gene Summary [Mouse]
Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissural neuron axon guidance; epithelial to mesenchymal transition; and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncam1 |
| Official Name | neural cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97281] |
| Ensembl ID | ENSMUSG00000039542 |
| Bio databases IDs | |
| Aliases | neural cell adhesion molecule 1 |
| Synonyms | Apha-1 NCAM, CD56, E-NCAM, MSK39, N-CAM, NCAM-C, neural cell adhesion molecule 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- palmitoylation site
- Immunoglobulin C1-set domain
- LRR-domain binding
- immunoglobulin domain
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- fibroblast growth factor receptor binding
- protein binding
- homophilic binding domain
- cytoskeletal protein binding
- cytoplasmic domain
- FN3
- Immunoglobulin like
- intracellular domain
- Immunoglobulin V-set domain
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- adenoma formation
- colorectal cancer
- pain
- metastasis
- covid-19 death
- liver cancer
- major depression
- non-insulin-dependent diabetes mellitus
role in cell
- phosphorylation in
- expression in
- quantity
- number
- proliferation
- apoptosis
- differentiation
- growth
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- raft fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- plasma membrane extracellular face
- microdomains
- presynaptic membrane
- postsynaptic membrane
- Golgi membrane
- neuromuscular junctions
- growth cone
- neurites
- synapse
- intercalated disks
- sarcolemma
- dense-core vesicles
- extracellular matrix
- basal lamina
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- exosomes
- plasma
- perivascular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- regulation of semaphorin-plexin signaling pathway
- epithelial to mesenchymal transition
- cell adhesion
- commissural neuron axon guidance
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- cytosol
- Golgi membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- viral receptor activity