Grik2 Gene Summary [Mouse]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Grik2 |
| Official Name | glutamate receptor, ionotropic, kainate 2 (beta 2) [Source:MGI Symbol;Acc:MGI:95815] |
| Ensembl ID | ENSMUSG00000056073 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, kainate 2 (beta 2) |
| Synonyms | AW124492, C130030K03Rik, EAA4, GLR6, GluK2, GluK2A, GluK2(Q), GLUK6, GLUR6, Glur beta-2, Glur β-2, glutamate ionotropic receptor kainate type subunit 2, Glutamate receptor channel subunit beta2, glutamate receptor, ionotropic, kainate 2 (beta 2), glutamate receptor, ionotropic, kainate 2 (β 2), MRT6, NEDLAS, RP23-433H22.3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grik2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Periplasmic binding protein
- identical protein binding
- ion channel
- kainate selective glutamate receptor
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- intracellular domain
- ubiquitin protein ligase binding
- Receptor family ligand binding region
- calcium channel
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate-gated ion channel
- enzyme binding
- extracellular ligand-gated ion channel
- protein binding
- glutamate receptor
- PDZ-domain binding
- PSD 95 binding domain
- neurotransmitter receptor
- ligand-gated ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Grik2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- bipolar disorder
- major depression
- dementia
- autosomal recessive mental retardation type 6
- mental retardation
- idiopathic scoliosis
- Huntington disease
- seizures
- neurodevelopmental disorder with impaired language and ataxia and with or without seizures
role in cell
- apoptosis
- proliferation
- loss
- cell death
- transmembrane potential
- activation
- depolarization
- long-term potentiation
- plasticity
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular compartment
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- cell-cell contacts
- presynaptic membrane
- postsynaptic membrane
- nerve ending
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grik2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- ion transmembrane transport
- positive regulation of synaptic transmission
- synaptic transmission
- receptor clustering
- positive regulation of neuron apoptotic process
- negative regulation of neuron apoptotic process
- cellular calcium ion homeostasis
- behavioral fear response
- glutamate receptor signaling pathway
- regulation of JNK cascade
- regulation of long-term neuronal synaptic plasticity
- regulation of inhibitory postsynaptic membrane potential
- regulation of synaptic transmission
- negative regulation of synaptic transmission, glutamatergic
- ionotropic glutamate receptor signaling pathway
- regulation of short-term neuronal synaptic plasticity
- neuron apoptotic process
- regulation of action potential in neuron
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- terminal button
- dendrite cytoplasm
- kainate selective glutamate receptor complex
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- ubiquitin conjugating enzyme binding
- identical protein binding
- kainate selective glutamate receptor activity
- ubiquitin protein ligase binding
- PDZ domain binding
- SNARE binding
- ionotropic glutamate receptor activity
- extracellular-glutamate-gated ion channel activity