Crot Gene Summary [Mouse]
Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crot |
| Official Name | carnitine O-octanoyltransferase [Source:MGI Symbol;Acc:MGI:1921364] |
| Ensembl ID | ENSMUSG00000003623 |
| Bio databases IDs | |
| Aliases | carnitine O-octanoyltransferase |
| Synonyms | 1200003H03Rik, Carnitine Octanoyltransferase, carnitine O-octanoyltransferase, COT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crot often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Choline/Carnitine o-acyltransferase
- enzyme
- protein binding
- carnitine O-octanoyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- lung carcinoma process
- diabetes mellitus
regulates
- long chain fatty acid
- coenzyme A
- octanoyl-coenzyme A
- acetyl-coenzyme A
- decanoyl-coenzyme A
- butyryl-coenzyme A
- propionyl-coenzyme A
- carnitine
- fatty acid
- acyl-coenzyme A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crot gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- fatty acid beta-oxidation
- fatty acid transport
- fatty acid beta-oxidation using acyl-CoA oxidase
- medium-chain fatty acid metabolic process
- coenzyme A metabolic process
- fatty acid metabolic process
- carnitine metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- carnitine O-octanoyltransferase activity