Ddx19b Gene Summary [Mouse]
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; orbito-sphenoid; and turbinate bone primordium. Orthologous to human DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx19b |
| Official Name | DEAD box helicase 19b [Source:MGI Symbol;Acc:MGI:2148251] |
| Ensembl ID | ENSMUSG00000033658 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 19b |
| Synonyms | 2810457M08Rik, 4921519L13Rik, DBP5, DDX19, DEAD-box helicase 19B, DEAD-box protein 19, RNAh, Zd10a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx19b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Pathways
Biological processes and signaling networks where the Ddx19b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ductal breast carcinoma
- ductal breast cancer
regulated by
- HOXA10
- T lymphocytes
- hematopoietic progenitor cells
role in cell
- accumulation in
- number
- alternative splicing in
- progression in
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear pores
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx19b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasmic stress granule
- cytoplasm
- membrane
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- mRNA binding
- helicase activity