Efna1 Gene Summary [Mouse]
Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; heart valve morphogenesis; and negative regulation of dendritic spine morphogenesis. Acts upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efna1 |
| Official Name | ephrin A1 [Source:MGI Symbol;Acc:MGI:103236] |
| Ensembl ID | ENSMUSG00000027954 |
| Bio databases IDs | |
| Aliases | ephrin A1 |
| Synonyms | B61, ECKLG, EFL1, EPGL1, Ephrin-A1, Epl1, EPLG1, GMAN, LERK-1, TNFAIP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Ephrin
- Cupredoxin superfamily
- ephrin receptor binding
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Efna1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- organismal death
- prostate cancer
- metastasis
- cancer
- uterine serous papillary cancer
- cervical cancer
- ulcerative colitis
- esophageal cancer
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- invasion
- survival
- retraction
- activation in
- autophagy in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- positive regulation of protein tyrosine kinase activity
- regulation of angiogenesis
- axon guidance
- endocardial cushion to mesenchymal transition involved in heart valve formation
- negative regulation of transcription from RNA polymerase II promoter
- regulation of peptidyl-tyrosine phosphorylation
- negative regulation of epithelial to mesenchymal transition
- regulation of axonogenesis
- angiogenesis
- negative regulation of thymocyte apoptotic process
- substrate adhesion-dependent cell spreading
- cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of dendritic spine morphogenesis
- aortic valve morphogenesis
- mitral valve morphogenesis
- cell-cell signaling
- positive regulation of MAPK cascade
- regulation of blood vessel endothelial cell migration
- regulation of cell adhesion mediated by integrin
- ephrin receptor signaling pathway
- positive regulation of protein phosphorylation
- protein stabilization
- notochord formation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- receptor binding