Ube2m Gene Summary [Mouse]
Predicted to enable NEDD8 transferase activity and ubiquitin-protein transferase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2m |
| Official Name | ubiquitin-conjugating enzyme E2M [Source:MGI Symbol;Acc:MGI:108278] |
| Ensembl ID | ENSMUSG00000005575 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2M |
| Synonyms | 2510040H03RIK, hUbc12, UBC12, UBC-RS2, ubiquitin-conjugating enzyme E2M |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD8 ligase
- Ubiquitin-conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2m gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- uterine leiomyoma
- leiomyomatosis
- non-insulin-dependent diabetes mellitus
- inflammatory swelling
- chronic epilepsy
- hepatic injury
- monoclonal gammopathy of undertermined significance
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- accumulation in
- JQ1 resistance
- ubiquitination in
- replication in
- cohesion in
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2m gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein neddylation
- post-translational protein modification
- positive regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- protein binding
- NEDD8 ligase activity