Wars2 Gene Summary [Mouse]
Predicted to enable tryptophan-tRNA ligase activity. Acts upstream of or within vasculogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wars2 |
| Official Name | tryptophanyl tRNA synthetase 2 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1917810] |
| Ensembl ID | ENSMUSG00000004233 |
| Bio databases IDs | |
| Aliases | tryptophanyl tRNA synthetase 2 (mitochondrial) |
| Synonyms | 5730427B17Rik, 9430020O07Rik, LOC683246, mtTrpRS, NEMMLAS, PKDYS3, TrpRS, tryptophanyl tRNA synthetase 2 (mitochondrial), tryptophanyl tRNA synthetase 2, mitochondrial |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tryptophan-tRNA ligase
- tRNA synthetases class I (W and Y)
- tryptophanyl-tRNA synthetase
- enzyme
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis
- male pattern hair loss
- mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis without seizures
- childhood-onset parkinsonism-dystonia type 3
- mitochondrial disorder
- mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis with seizures
- neurodevelopmental disorder
- alopecia
- major depression
regulated by
- DOHH
- TP73
regulates
- L-tryptophan
- pyrophosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- mitochondrial tryptophanyl-tRNA aminoacylation
- vasculogenesis
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tryptophan-tRNA ligase activity