Dohh Gene Summary [Mouse]
Enables deoxyhypusine monooxygenase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Predicted to be active in cytosol. Is expressed in nervous system; retina; and skeletal muscle. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dohh |
| Official Name | deoxyhypusine hydroxylase/monooxygenase [Source:MGI Symbol;Acc:MGI:1915964] |
| Ensembl ID | ENSMUSG00000078440 |
| Bio databases IDs | |
| Aliases | deoxyhypusine hydroxylase/monooxygenase |
| Synonyms | 1110033C18Rik, deoxyhypusine hydroxylase, deoxyhypusine hydroxylase/monooxygenase, Dohh.1, hDOHH, HLRC1, NEDMVIC, RGD1304783 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dohh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E-Z type HEAT repeats
- PBS lyase HEAT-like repeat
- HEAT repeat
- N-terminal dyad arm
- C-terminal dyad arm
- deoxyhypusine monooxygenase
- immunoglobulin variable region-like domain
- iron ion binding
- enzyme
- protein binding
- HEAT repeats
Pathways
Biological processes and signaling networks where the Dohh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment
- chronic obstructive pulmonary disease
- nonalcoholic steatohepatitis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
regulated by
- ZFHX3
- DL-fructose
- myoblasts
- cigarette smoke
- palmitic acid
- oleic acid
role in cell
- proliferation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dohh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-lysine modification to hypusine
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- deoxyhypusine monooxygenase activity