Etfb Gene Summary [Mouse]
Predicted to enable electron transfer activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; eye; nervous system; and urinary system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFB (electron transfer flavoprotein subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etfb |
| Official Name | electron transferring flavoprotein, beta polypeptide [Source:MGI Symbol;Acc:MGI:106098] |
| Ensembl ID | ENSMUSG00000004610 |
| Bio databases IDs | |
| Aliases | electron transferring flavoprotein, beta polypeptide |
| Synonyms | 0610009I16Rik, 2810441H06Rik, electron transfer flavoprotein subunit beta, electron transfer flavoprotein subunit β, electron transferring flavoprotein, beta polypeptide, electron transferring flavoprotein, β polypeptide, FP585, MADD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Etfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- Electron transfer flavoprotein domain
- protein binding
- Adenine nucleotide alpha hydrolase (AANH) superfamily
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- glutaric aciduria type 2
- glutaric acidemia type 2B
- organismal death
regulates
- amino acids
- oxygen
role in cell
- growth
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Etfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular amino acid catabolic process
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- respiratory electron transport chain
Cellular Component
Where in the cell the gene product is active
- electron transfer flavoprotein complex
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- electron carrier activity