Nkg7 Gene Summary [Mouse]
Involved in several processes, including CD4-positive, alpha-beta T cell activation; defense response to other organism; and granzyme-mediated programmed cell death signaling pathway. Located in cytolytic granule. Is expressed in ductus deferens; epididymis; esophagus; prostate gland; and thymus primordium. Orthologous to human NKG7 (natural killer cell granule protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkg7 |
| Official Name | natural killer cell group 7 sequence [Source:MGI Symbol;Acc:MGI:1931250] |
| Ensembl ID | ENSMUSG00000004612 |
| Bio databases IDs | |
| Aliases | natural killer cell group 7 sequence |
| Synonyms | 2500004F03Rik, GIG1, GMP-17, natural killer cell granule protein 7, natural killer cell group 7 sequence, p15-TIA-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkg7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkg7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- positive regulation of inflammatory response
- killing of cells of other organism
- natural killer cell degranulation
- natural killer cell mediated cytotoxicity
- CD4-positive, alpha-beta T cell activation
- natural killer cell mediated cytotoxicity directed against tumor cell target
- defense response to protozoan
Cellular Component
Where in the cell the gene product is active
- cytolytic granule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding